30-Year Trend (Skin Booster Market)
| Category | Degradability | Mechanism of Action | Key Ingredients | Entry year | Market Size KOR/GLOBAL |
Original Tech Companies |
Major Companies |
Trend Shift 2023 |
|||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Immediate | Wrinkle / Contour Improvement |
Biodegradable | Nerve Signal Blocking | Botulinum Toxin | 2002 | 0.25 Tri/7 Tri | Approx. 20 | Allergan |
Trend Shift
2023 Before/After
Preference for immediate visible effects
Prioritizing solutions that fundamentally resolve root causes over time
|
||
| Simple Volume Enhancement |
Non- Biodegradable |
Silicone | 1976 | . | 100 + | Dowcorning | |||||
| Biodegradable | Crosslinked | HA Filler | 1996 | 0.2 Tri / 6 Tri | Galderma | ||||||
| Non/Low-crosslinked | HA Skin Booster | 2004 | . | ||||||||
| Collagen Density Replenishment |
Biodegradable | Heterogeneous collagen | Collagen Filler | 1981 | . | Allergan | |||||
| Homogeneous collagen |
Extraction / Process | Collagen Filler | 2024 | 0.02 Tri | 3 | L&C Bio | |||||
| Genetic Recombinant | Collagen Filler | X | . | . | . | ||||||
| Fundamental | Collagen Synthesis |
Non- Biodegradable |
PMMA | 1994 | . | Approx. 5 | Suneva Medical | ||||
| Biodegradable |
Inflammation O
Macrophage
Recruitment ▼ Cytokine Secretion ▼ Fibroblast Activation ▼ Collagen Production |
Low Duration | Tensile Force X | PDLLA | 2014 | 0.05 Tri/0.05 Tri | 3 | VAIM | |||
| Tensile Force O | PDO | 2020 | 0.02 Tri | 2 | Ultra V | ||||||
| Medium Duration | PLLA | 1999 | 0.1 Tri/2 Tri | Approx. 15 | Galderma | ||||||
| High Duration | PCL | 2009 | 0.1 Tri/1 Tri | Approx. 5 | Sinclair | ||||||
| Inflammation X | High Duration | CaHA | 2003 | 0.05/1Tri | Approx. 5 | Merz | |||||
| Cell Regeneration | Biodegradable | Inflammation X | Simple Cellular Signaling |
Low Molecular | PDRN | 2008 | 0.25 Tri/0.3 Tri | Approx. 10 | Pharma Research |
||
| High Molecular | PN | 2014 | |||||||||
| Complex Cellular Signaling |
Exosome | X | 0.05 Tri/2.5 Tri | Approx. 15 | ExoCoBio | ||||||
| Complex Growth Factors |
X | . | . | . | |||||||
BOTOX / FILLER
Botulinum Toxin
Temporarily paralyzes muscles by inhibiting the secretion of acetylcholine, a neurotransmitter. Broadly applied for dynamic facial wrinkle improvement, masseter reduction, and body contouring.
Reference Videos
HA Filler
A substance that increases viscoelasticity in the body by cross-linking hyaluronic acid, a natural component of the human body. It excels in immediate volumization and is the gold standard filler, with proven high safety as it can be dissolved at any time using hyaluronidase.
Reference Videos
SKIN BOOSTERS
PMMA
Polymethyl methacrylate
Features: Composed of non-degradable microspheres, providing semi-permanent effects. Induces the formation of a collagen capsule to fill volume deficits.
PLLA
Poly-L-lactic acid
Features: A biodegradable synthetic polymer that gradually degrades in the body, inducing robust autologous collagen production through a foreign body reaction. (e.g., Sculptra)
CaHA
Calcium Hydroxylapatite
Features: Composed of minerals found in bones and teeth. Provides immediate volume upon injection while simultaneously stimulating collagen production. (e.g., Radiesse)
PCL
Polycaprolactone
Features: A fully biodegradable material combining the immediate effects of HA fillers with the collagen-stimulating properties of PLLA. Offers an extended duration of 1 to 4 years. (e.g., Ellansé)
PDO
Polydioxanone
Features: An injectable form created by micro-pulverizing (microspheres) a highly safe material traditionally used for surgical dissolving sutures (lifting threads). (e.g., UltraCol)
PDLLA
Poly-D,L-lactic acid
Features: An isomer of PLLA featuring smooth, round particles with a porous, sponge-like internal structure, minimizing tissue irritation. (e.g., Juvelook)
ECM (Extracellular Matrix)
ECM Modulators
Extracellular Matrix (ECM) provides the essential structural and biochemical support to surrounding cells. By injecting or stimulating ECM components directly, these advanced therapies promote tissue regeneration, improve cellular environments, and fundamentally restore skin elasticity and overall health.
Allogeneic vs. Porcine ECM
Understanding the source of ECM materials is crucial. This video explains the differences between allogeneic (human-derived) and porcine (pig-derived) ECM, highlighting the specific advantages and rationale for utilizing porcine ECM in regenerative aesthetics.
PATENTED MATERIALS
PATENTED
MATERIALS
Chitogen Chitogen™
A chitosan-based bio-hydrogel utilizing LTG (Liquid To Gel) technology.
Watch Tech SummaryRegentrix Regentrix™
A decellularized extracellular matrix (dECM) produced via a supercritical carbon dioxide process.
Watch Tech SummaryChitogenics Chitogenics™
An advanced formulation technology that optimally merges superior proprietary technologies (Chitogen + Regentrix) specifically for the aesthetic field.
FAQ
Q. Can molecules exceeding 500 Daltons be absorbed into the dermis?
Detailed explanations regarding this question and the skin absorption mechanism (the 500 Dalton Rule) can be found in the answer video below.
Watch Answer Video